We developed an efficient palladium-catalyzed synthesis of benzazepine derivatives from ( E,Z )-3-(arylidene)indolin-2-ones with alkynes, affording the desired products in good yields. The reaction proceeds via a palladium-catalyzed C−H/N−H activation,… Click to show full abstract
We developed an efficient palladium-catalyzed synthesis of benzazepine derivatives from ( E,Z )-3-(arylidene)indolin-2-ones with alkynes, affording the desired products in good yields. The reaction proceeds via a palladium-catalyzed C−H/N−H activation, followed by alkyne insertion and reductive elimination sequences. Furthermore, we have also demonstrated the gram scale reaction as well as some synthetic transformations of the annulated products.
Keywords:
arylidene indolin;
synthesis benzazepine;
ones alkynes;
benzazepine derivatives;
indolin ones
Journal Title: Synlett
Year Published: 2025
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Journal Title: Synlett
Year Published: 2025
Link to full text (if available)
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recommendations!