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A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively… Click to show full abstract
A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively to afford a wide variety of substituted NH-pyrroles in good yields.
Keywords:
blaise reaction;
substituted pyrroles;
reaction intermediate;
synthesis substituted;
one pot
Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!