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We describe a convenient method for the synthesis of multisubstituted allenes from cross-coupling of propargyl acetates with organoaluminum reagent: The reaction of propargyl acetates with 1.2 equivalents of organoaluminum reagent mediated… Click to show full abstract
We describe a convenient method for the synthesis of multisubstituted allenes from cross-coupling of propargyl acetates with organoaluminum reagent: The reaction of propargyl acetates with 1.2 equivalents of organoaluminum reagent mediated by Pd(PPh 3 ) 2 Cl 2 (1 mol%)/Ph 3 P (2 mol%) and K 2 CO 3 in THF may produce tri- or tetrasubstituted allenes in good to excellent yields (83–94%) and high regioselectivities (up to 99%) at 60 °C in 3–4 hours.
Keywords:
organoaluminum reagent;
multisubstituted allenes;
synthesis multisubstituted;
propargyl acetates;
cross coupling
Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!