LAUSR

An efficient and modular synthetic route to the bidentate C3*-TunePhos was developed, which allowed tunable steric and electronic effects of the ligands. This novel chemical technology highlights a versatile C3*-dibromodiphenyl intermediate that was accomplished by in situ Grignard exchange and subsequent Cu(II)-mediated intra­molecular oxidative radical coupling process. It is worth noting that this advanced intermediate not only could be easily prepared by a diverse array of C3*-TunePhos-type ligands, but also could be used to facile synthesis of other novel type of N,S-centered bidentate ligands.