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Aqueous-Medium Selective Modification of Cysteine and Related Thiols with Tricyclic Oxygen-Heterocycles

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The utility of tricyclic oxygen-heterocycles as a reagent for the thiol-selective modification toward bioconjugation was demonstrated by the use of l -cysteine, homocysteine, captopril, and glutathione as a nucleophile having… Click to show full abstract

The utility of tricyclic oxygen-heterocycles as a reagent for the thiol-selective modification toward bioconjugation was demonstrated by the use of l -cysteine, homocysteine, captopril, and glutathione as a nucleophile having a thiol group. These trapping reactions proceeded under the mild and aqueous reaction conditions.

Keywords: tricyclic oxygen; oxygen heterocycles; selective modification; cysteine

Journal Title: Synthesis
Year Published: 2017

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