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Convenient Synthesis of Oxazolo[5,4-h]pyrrolo[4,3,2-de]quino­lones via Hypervalent Iodine Mediated Intramolecular Oxidative Cyclization

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A convenient and practical method has been developed for the synthesis of substituted oxazolo[5,4- h ]pyrrolo[4,3,2- de ]quinolones via the intramolecular oxidative cyclization by using PIFA as oxidant and TMSOTf… Click to show full abstract

A convenient and practical method has been developed for the synthesis of substituted oxazolo[5,4- h ]pyrrolo[4,3,2- de ]quinolones via the intramolecular oxidative cyclization by using PIFA as oxidant and TMSOTf as additive in DCE under an air atmosphere. The reaction proceeds in good yields and has good functional groups tolerance.

Keywords: intramolecular oxidative; oxazolo pyrrolo; convenient synthesis; synthesis; oxidative cyclization

Journal Title: Synthesis
Year Published: 2017

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