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An N-heterocyclic carbene (NHC)-catalyzed asymmetric [4+2] annulation of ( E )-2-benzoyl-3-phenylacrylonitriles with α-chloroaldehydes has been developed. The protocol leads to 5-cyano-substituted dihydropyranones in good to excellent yields with excellent diastereo-… Click to show full abstract
An N-heterocyclic carbene (NHC)-catalyzed asymmetric [4+2] annulation of ( E )-2-benzoyl-3-phenylacrylonitriles with α-chloroaldehydes has been developed. The protocol leads to 5-cyano-substituted dihydropyranones in good to excellent yields with excellent diastereo- and enantioselectivities (up to 93% yield, >20:1 d.r. and 99% ee).
Keywords:
cyano substituted;
catalyzed activation;
carbene catalyzed;
substituted dihydropyranones;
synthesis;
heterocyclic carbene
Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
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recommendations!