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General routes for the synthesis of 1,3-oxazin-4-ones are discussed, with particular attention paid to recent developments in the field. The syntheses of amine functionalised cyclopropyl carbinols via a hydride-mediated reduction… Click to show full abstract
General routes for the synthesis of 1,3-oxazin-4-ones are discussed, with particular attention paid to recent developments in the field. The syntheses of amine functionalised cyclopropyl carbinols via a hydride-mediated reduction of various 5-chloroethyl-1,3-oxazin-4-enones in moderate to good yield are disclosed. This new method provides an opportunity to access greater structural diversity within these useful synthetic building blocks.
Keywords:
free synthesis;
cyclopropyl;
oxazinones reductive;
synthesis oxazinones;
cyclopropyl carbinols;
metal free
Journal Title: Synthesis
Year Published: 2017
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Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!