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A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of… Click to show full abstract
A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.
Keywords:
total synthesis;
first total;
synthesis cytotoxic;
aaptamine;
synthesis
Journal Title: Synthesis
Year Published: 2017
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Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
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recommendations!