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A stereospecific synthesis of the tetrahydro-2 H -indeno[1,2- b ]furan skeleton, which is embedded in bioactive aromatic strigolactones such as GR24, is realized by a nickel-mediated tandem cross-coupling for the… Click to show full abstract
A stereospecific synthesis of the tetrahydro-2 H -indeno[1,2- b ]furan skeleton, which is embedded in bioactive aromatic strigolactones such as GR24, is realized by a nickel-mediated tandem cross-coupling for the first time. The observed cis -stereoselectivity during the intramolecular formation of the Csp 3 –Csp 2 bond is rationalized through conformation analysis and DFT calculations.
Keywords:
cascade short;
nickel promoted;
cyclization cascade;
reductive cyclization;
promoted reductive;
synthesis
Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!