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A metal-free oxidative coupling reaction of trifluoromethyl β-diketones with alcohols for the synthesis of α-keto esters in good to excellent yields has been developed. Preliminary mechanistic studies suggest that an… Click to show full abstract
A metal-free oxidative coupling reaction of trifluoromethyl β-diketones with alcohols for the synthesis of α-keto esters in good to excellent yields has been developed. Preliminary mechanistic studies suggest that an I2/TBHP promoted sequential iodination, C–C bond cleavage, C–O bond formation and oxidation pathway is involved in this reaction.
Keywords:
diketones alcohols;
bond;
tbhp promoted;
keto esters;
trifluoromethyl diketones;
bond cleavage
Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!