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A series of new 3-substituted-4-iodo-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yl)oxidanyl compounds is synthesized to achieve NH2- and SH-specific spin labels. The new vinyl iodides are tested in Sonogashira and Buchwald–Hartwig cross-coupling reactions to produce a… Click to show full abstract
A series of new 3-substituted-4-iodo-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yl)oxidanyl compounds is synthesized to achieve NH2- and SH-specific spin labels. The new vinyl iodides are tested in Sonogashira and Buchwald–Hartwig cross-coupling reactions to produce a paramagnetic β-amino acid ester, pyrroline nitroxide-condensed heterocycles, including a paramagnetic α,α′-dipyridyl ligand and a spin-labeled sulfonamide.
Keywords:
palladium copper;
vinyl;
cross coupling;
coupling reactions;
copper catalyzed
Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!