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A copper-catalyzed approach for the synthesis of 1-acyloxy-2,2,6,6-tetramethylpiperidines through the C–C bond cleavage of cyclic or acyclic ketones was developed. In this chemistry, a combination of CuCl2·2H2O, 1,10-phenanthroline monohydrate, and… Click to show full abstract
A copper-catalyzed approach for the synthesis of 1-acyloxy-2,2,6,6-tetramethylpiperidines through the C–C bond cleavage of cyclic or acyclic ketones was developed. In this chemistry, a combination of CuCl2·2H2O, 1,10-phenanthroline monohydrate, and aniline was crucial for the formation of the desired products by the reaction of ketones with TEMPO. This research provides a new strategy for the further transformation of α-aryl cyclic or acyclic ketones.
Keywords:
acyclic ketones;
acyloxy tetramethylpiperidines;
cyclic acyclic;
synthesis acyloxy;
copper catalyzed
Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!