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Enantioselective intramolecular decarboxylative allylation of β-keto esters catalyzed by a palladium bis(phosphine)-thiourea complex is reported. This procedure is not only effective for β-keto esters, but also effective for β-keto amides.… Click to show full abstract
Enantioselective intramolecular decarboxylative allylation of β-keto esters catalyzed by a palladium bis(phosphine)-thiourea complex is reported. This procedure is not only effective for β-keto esters, but also effective for β-keto amides. An intermolecular variant of the asymmetric decarboxylative allylation is also established. DFT calculations indicate that an outer-sphere mechanism is viable for the decarboxylative allylation of β-keto esters.
Keywords:
decarboxylative allylation;
keto esters;
allylation keto;
keto;
palladium
Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!