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Highly Selective Approach to α-Iodoketones from Aminoalkynols with Iodine Monochloride

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A protocol has been developed to achieve selective and direct synthesis of α-iodoketones under mild condition, from the reaction of aminoalkynols with iodine monochloride. The scope of the reaction was… Click to show full abstract

A protocol has been developed to achieve selective and direct synthesis of α-iodoketones under mild condition, from the reaction of aminoalkynols with iodine monochloride. The scope of the reaction was investigated using various aminoalkynols with iodine monochloride and the corresponding α-iodoketones were obtained selectively without forming iodocyclized and/or addition products.

Keywords: highly selective; aminoalkynols iodine; iodine monochloride; selective approach; approach iodoketones; iodoketones aminoalkynols

Journal Title: Synthesis
Year Published: 2017

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