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Efficient Method to Synthesize Benzhydrazides by In Situ Oxidation/Coupling of Benzylic Alcohols with Azodicarboxylates

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An efficient synthesis of benzhydrazides has been achieved through the direct acylation of azodicarboxylates with benzylic alcohols in moderate to high yields. The method represents the first practical approach to… Click to show full abstract

An efficient synthesis of benzhydrazides has been achieved through the direct acylation of azodicarboxylates with benzylic alcohols in moderate to high yields. The method represents the first practical approach to amides containing a hydrazine structural unit from benzylic alcohols.

Keywords: efficient method; benzhydrazides situ; benzylic alcohols; synthesize benzhydrazides; situ oxidation; method synthesize

Journal Title: Synlett
Year Published: 2018

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