An efficient Pd(0)-catalyzed alkylarylation of N-alkyl-N-methacryloylbenzamides with alkyl iodides for the synthesis of isoquinoline-1,3-diones is described. A highlight of the method is its excellent functional-group tolerance. Mechanistic investigations suggest that… Click to show full abstract
An efficient Pd(0)-catalyzed alkylarylation of N-alkyl-N-methacryloylbenzamides with alkyl iodides for the synthesis of isoquinoline-1,3-diones is described. A highlight of the method is its excellent functional-group tolerance. Mechanistic investigations suggest that a radical addition/cyclization process is probably involved in the sequences.
Keywords:
alkylarylation alkyl;
catalyzed alkylarylation;
alkyl iodides;
methacryloylbenzamides alkyl;
alkyl methacryloylbenzamides
Journal Title: Synlett
Year Published: 2018
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Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
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recommendations!