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A method to convert tertiary N -propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating.… Click to show full abstract
A method to convert tertiary N -propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating. It is also applicable to N -propargyl lactams and tends to populate the so-called ‘lead-like’ chemistry space.
Keywords:
efficient conversion;
propargylamides imidazoles;
conversion tertiary;
via hydroamination;
tertiary propargylamides;
imidazoles via
Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!