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Inter- and intramolecular carbonyl-ene reactions have been developed using 5 mol% Fe(BF 4 ) 2 as catalyst, affording homoallylic alcohols in 36–87% isolated yields. This catalyst, prepared from FeCl 2… Click to show full abstract
Inter- and intramolecular carbonyl-ene reactions have been developed using 5 mol% Fe(BF 4 ) 2 as catalyst, affording homoallylic alcohols in 36–87% isolated yields. This catalyst, prepared from FeCl 2 and AgBF 4 , is the first Fe II Lewis acid reported for the carbonyl-ene reaction using ethyl trifluoropyruvate. The method was successfully applied to the reaction of various 1,1-disubstituted alkenes with ethyl trifluoropyruvate and to the cyclization of citronellal.
Keywords:
carbonyl ene;
intramolecular carbonyl;
ene;
ene reaction;
inter intramolecular
Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!