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A key intermediate was obtained as solid through filtration of the reaction mixture of saccharin, chloro(triphenyl)phosphonium chloride, and N,N-diisopropylethylamine (DIPEA) in chloroform. The soluble triphenylphosphine oxide went to filtrate as… Click to show full abstract
A key intermediate was obtained as solid through filtration of the reaction mixture of saccharin, chloro(triphenyl)phosphonium chloride, and N,N-diisopropylethylamine (DIPEA) in chloroform. The soluble triphenylphosphine oxide went to filtrate as waste, while the solid was reacted with amines to afford N-sulfonylamidines. In total, 26 N-sulfonylamidine products were obtained in moderate to good overall yields.
Keywords:
saccharin;
sulfonylamidine;
saccharin derivatives;
convenient synthetic;
approach saccharin;
synthetic approach
Journal Title: Synthesis
Year Published: 2018
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Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!