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tert-Butylhydroperoxide-Mediated Oxidation of Carbazole-3-carboxyaldehydes

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Oxidation of carbazole-3-carboxyaldehydes promoted by a 70% aqueous solution of tert -butylhydroperoxide leads to the corresponding carbazole-3-carboxylic acids in good yields. This transition-metal-free oxidation protocol is attractive for the synthesis… Click to show full abstract

Oxidation of carbazole-3-carboxyaldehydes promoted by a 70% aqueous solution of tert -butylhydroperoxide leads to the corresponding carbazole-3-carboxylic acids in good yields. This transition-metal-free oxidation protocol is attractive for the synthesis of pharmaceutically important carbazole analogues.

Keywords: tert butylhydroperoxide; butylhydroperoxide mediated; oxidation; carbazole carboxyaldehydes; oxidation carbazole; carbazole

Journal Title: Synlett
Year Published: 2018

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