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A palladium-catalyzed ligand controlled regioselective coupling reaction of secondary propargyl carbonates and ethyl 2-(pyridin-2-yl)acetate derivatives has been described, leading to C-3 benzylated indolizines for the first time in moderate to… Click to show full abstract
A palladium-catalyzed ligand controlled regioselective coupling reaction of secondary propargyl carbonates and ethyl 2-(pyridin-2-yl)acetate derivatives has been described, leading to C-3 benzylated indolizines for the first time in moderate to good yields. DBFphos as the ligand is crucial to this high regioselective annulation reaction, and a plausible reaction mechanism has been proposed.
Keywords:
regioselective coupling;
secondary propargyl;
palladium catalyzed;
carbonates ethyl;
ethyl pyridin;
propargyl carbonates
Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!