A metal-free protocol for Minisci C–H alkylation of heteroarenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of Bronsted acid has been demonstrated. A series… Click to show full abstract
A metal-free protocol for Minisci C–H alkylation of heteroarenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of Bronsted acid has been demonstrated. A series of alkyl substituted heteroarenes were readily prepared by the C–H alkylation in moderate to good yields. A possible pathway involving the addition of alkyl radical to heterocycle followed by rearomatization is described.
Keywords:
nsted acid;
alkyl peroxides;
acid promoted;
approach nsted;
metal free;
free approach
Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!