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A procedure for the α-arylation of α,α-disubstituted esters and ketones to generate quaternary carbon centers is described. The developed protocol is operationally simple and employs an air- and moisture-stable dinuclear… Click to show full abstract
A procedure for the α-arylation of α,α-disubstituted esters and ketones to generate quaternary carbon centers is described. The developed protocol is operationally simple and employs an air- and moisture-stable dinuclear Pd(I) complex [Pd(μ-I)(Pt-Bu3)]2 to mediate selective α-arylation of aromatic C–I/Br bonds in the presence of aromatic C–Cl and/or C–OTf sites.
Keywords:
ketones enabled;
bench stable;
arylation;
arylation esters;
enabled bench;
esters ketones
Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!