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The synthesis of pharmacologically relevant scaffolds is an important goal in modern organic chemistry. For this reason, the use of methodologies involving operationally simple procedures and easily handled reagents to… Click to show full abstract
The synthesis of pharmacologically relevant scaffolds is an important goal in modern organic chemistry. For this reason, the use of methodologies involving operationally simple procedures and easily handled reagents to chemoselectively and stereoselectively convert different functionalities has gained considerable attention. In this review, we summarize the latest trends in reductive reactions using triethylÂsilane as the key reagent that provide synthetically interesting intermediates, coupling products and structures with control of the 3D architecture. 1 Introduction 2 Scenario A: Reduction of C–C Multiple Bonds 3 Scenario B: Reduction of Functional Groups 4 Scenario C: Reductive Coupling 5 Scenario D: Reductive Cyclization 6 Conclusion
Journal Title: Synthesis
Year Published: 2018
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