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Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against… Click to show full abstract
Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.
Keywords:
properties bifunctional;
bifunctional allocolchicine;
antiproliferative properties;
synthesis antiproliferative;
allocolchicine derivatives;
allocolchicine
Journal Title: Synthesis
Year Published: 2018
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Journal Title: Synthesis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!