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A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed.… Click to show full abstract
A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis
Keywords:
amino;
tertiary enamides;
nucleophilic addition;
intramolecular nucleophilic;
synthesis
Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!