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An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with esters catalyzed by Fe(ClO4)3·H2O is described. Fe(ClO4)3·H2O is an economically efficient catalyst for the Ritter… Click to show full abstract
An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with esters catalyzed by Fe(ClO4)3·H2O is described. Fe(ClO4)3·H2O is an economically efficient catalyst for the Ritter reaction under solvent-free conditions. Reactions of a range of esters (benzyl, sec-alkyl, and tert-butyl esters) with nitriles (primary, secondary, tertiary, and aryl nitriles) were performed to provide the corresponding amides in high to excellent yields.
Keywords:
clo4 h2o;
synthesis;
ritter reaction;
esters nitriles
Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!