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A concise total synthesis of (+)-aphanorphine is described. The key features of the strategy include a Pd-catalyzed intermolecular trimethylenemethane [3+2]-cycloaddition to form ring C and a Co-catalyzed radical cyclization through… Click to show full abstract
A concise total synthesis of (+)-aphanorphine is described. The key features of the strategy include a Pd-catalyzed intermolecular trimethylenemethane [3+2]-cycloaddition to form ring C and a Co-catalyzed radical cyclization through a hydrogen-atom transfer to close ring B. The synthesis was completed in six steps.
Keywords:
synthesis aphanorphine;
total synthesis;
synthesis;
concise total
Journal Title: Synlett
Year Published: 2021
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!