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Synthesis of Multisubstituted Guanidines through Palladium-Catalyzed Insertion of Isonitriles

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A new method for the synthesis of multisubstituted guanidines through tandem intermolecular insertion of isonitriles with un­activated amides has been developed. In this study, isonitriles could be used not only… Click to show full abstract

A new method for the synthesis of multisubstituted guanidines through tandem intermolecular insertion of isonitriles with un­activated amides has been developed. In this study, isonitriles could be used not only as reaction materials but also as the source of amines.

Keywords: synthesis multisubstituted; multisubstituted guanidines; insertion isonitriles; palladium catalyzed; guanidines palladium

Journal Title: Synlett
Year Published: 2018

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