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β-Alkoxycarbonyl-γ-lactams and γ-alkoxycarbonyl-δ-lactams were synthesized via a conjugate alkylation/Mannich reaction/lactamization tandem reaction of unsaturated dicarboxylates with diethyl zinc and aldimines. The high yield, the ready availability of the reagents, and… Click to show full abstract
β-Alkoxycarbonyl-γ-lactams and γ-alkoxycarbonyl-δ-lactams were synthesized via a conjugate alkylation/Mannich reaction/lactamization tandem reaction of unsaturated dicarboxylates with diethyl zinc and aldimines. The high yield, the ready availability of the reagents, and especially the high diastereoselectivity are promising characteristics of the approach that allows access to functionalized lactams.
Keywords:
tandem reaction;
diastereoselective synthesis;
synthesis lactams;
via conjugate;
reaction
Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
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recommendations!