Photo by voznenko_artur from unsplash
RCAI-56 is a synthetic glycolipid exhibiting a potent antitumor activity by stimulation of natural killer T cells. Tetra-O-benzyl-α-carbagalactose, an important synthetic segment of RCAI-56, was stereoselectively synthesized from 1,4-dichloro-2-butene in… Click to show full abstract
RCAI-56 is a synthetic glycolipid exhibiting a potent antitumor activity by stimulation of natural killer T cells. Tetra-O-benzyl-α-carbagalactose, an important synthetic segment of RCAI-56, was stereoselectively synthesized from 1,4-dichloro-2-butene in nine steps, including the key step of organocatalytic asymmetric Diels–Alder reaction between acrolein and 1-benzyloxybutadiene.
Keywords:
stereocontrolled synthesis;
rcai;
concise stereocontrolled;
segment rcai;
synthesis carbagalactose
Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!