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Synthesis of N-Pyridyl Hydroxylamines via Copper-Catalyzed Cross-Coupling

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N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28–90%… Click to show full abstract

N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28–90% yield.

Keywords: cross coupling; pyridyl; catalyzed cross; via copper; copper catalyzed

Journal Title: Synthesis
Year Published: 2019

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