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Chiral α-chloro-α-fluoro ketones were synthesized by enantioselective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with moderate-to-high enantioselectivity… Click to show full abstract
Chiral α-chloro-α-fluoro ketones were synthesized by enantioselective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with moderate-to-high enantioselectivity (up to 90% ee). The method was also applied to the synthesis of α-bromo-α-chloro ketones with 90% ee.
Keywords:
halo;
synthesis;
ketocarboxylic acids;
decarboxylative chlorination;
chloro
Journal Title: Synthesis
Year Published: 2019
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Journal Title: Synthesis
Year Published: 2019
Link to full text (if available)
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recommendations!