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An efficient, metal-free oxidative coupling of tetrahydroisoquinolines and 3-fluorooxindoles on water has been developed. Using aqueous tert-butyl hydroperoxide as the oxidant, Et3N as the base, and water as the sole… Click to show full abstract
An efficient, metal-free oxidative coupling of tetrahydroisoquinolines and 3-fluorooxindoles on water has been developed. Using aqueous tert-butyl hydroperoxide as the oxidant, Et3N as the base, and water as the sole solvent, a variety of 3-fluorooxindoles fully substituted at the 3-position and containing a tetrahydroisoquinoline fragment has been successfully prepared in yields of up to 93% with an anti/syn stereoselectivity of up to 99:1 under very mild and safe reaction conditions.
Keywords:
tetrahydroisoquinolines fluorooxindoles;
water;
free oxidative;
coupling tetrahydroisoquinolines;
oxidative coupling;
metal free
Journal Title: Synthesis
Year Published: 2019
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Journal Title: Synthesis
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!