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Difluoromethyl groups are of great importance to synthetic and pharmaceutical chemistry because of their unique properties that regulate molecular bioactivity. In this article, approaches towards difluoromethylation are discussed and the… Click to show full abstract
Difluoromethyl groups are of great importance to synthetic and pharmaceutical chemistry because of their unique properties that regulate molecular bioactivity. In this article, approaches towards difluoromethylation are discussed and the development of the first aliphatic decarboxylative difluoromethylation reaction is detailed. With a broad scope, the real-world utility of the protocol is demonstrated.
Keywords:
late stage;
aliphatic carboxylic;
carboxylic acids;
difluoromethylation aliphatic;
difluoromethylation;
stage difluoromethylation
Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!