A fast and highly enantioselective chlorination of 4-pyrazolones catalyzed by bis(oxazoline)–Cu(ClO4)2·6H2O complexes has been developed. Under the optimized conditions, a series of pyrazolones bearing stereogenic chlorine-attached carbon centers were obtained… Click to show full abstract
A fast and highly enantioselective chlorination of 4-pyrazolones catalyzed by bis(oxazoline)–Cu(ClO4)2·6H2O complexes has been developed. Under the optimized conditions, a series of pyrazolones bearing stereogenic chlorine-attached carbon centers were obtained in moderate to high yields (up to 98%) and with enantioselectivities of up to 98% ee.
Keywords:
chlorination substituted;
asymmetric chlorination;
chlorination;
catalyzed chiral;
pyrazolones catalyzed;
substituted pyrazolones
Journal Title: Synlett
Year Published: 2020
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Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!