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N-Phosphorylated Pyrrolidines: An Overview of Synthetic Approaches

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Organophosphorus pyrrolidine derivatives possessing P–N bonds are a promising yet underexplored class of compounds. In this short review we overview the general approaches to these compounds described so far, with… Click to show full abstract

Organophosphorus pyrrolidine derivatives possessing P–N bonds are a promising yet underexplored class of compounds. In this short review we overview the general approaches to these compounds described so far, with a special emphasis on their asymmetric synthesis. 1 Introduction 2 Synthesis of Pyrrolidine-Based P(III) Derivatives 3 Synthesis of Pyrrolidine-Based P(V) Derivatives 3.1 Phosphorylation of Pyrrolidines with P(V) Acid Chlorides 3.2 Phosphorylation of Pyrrolidines with P(V) Acid Esters 3.3 Syntheses via the Atherton–Todd Reaction 3.4 Oxidation of Pyrrolidine-Based P(III) Derivatives 4 Syntheses of N-Phosphorylpyrrolidines from Acyclic Precursors 5 Conclusions

Keywords: pyrrolidines overview; pyrrolidine based; pyrrolidine; phosphorylated pyrrolidines; overview synthetic; synthetic approaches

Journal Title: Synthesis
Year Published: 2020

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