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An original metal-free regio- and stereoselective intermolecular hydroamination of alkynes is described. Various (E)-enamines were obtained from arylacetylenes and aliphatic secondary amines in the presence of ethylene glycol as a… Click to show full abstract
An original metal-free regio- and stereoselective intermolecular hydroamination of alkynes is described. Various (E)-enamines were obtained from arylacetylenes and aliphatic secondary amines in the presence of ethylene glycol as a solvent. The latter is assumed to play a major role in the mechanism through hydrogen bonding and proton exchange.
Keywords:
promoted metal;
hydroamination alkynes;
hydrogen bond;
bond promoted;
metal free
Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!