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The reaction of 2-unsubstituted imidazole N-oxides with ethyl cyanoacetate and aromatic aldehydes leads to the formation of ethyl 2-cyano-2-(1,3-dihydro-2H-imidazole-2-ylidene)acetates. The reaction proceeds through an initial [3+2] cycloaddition, followed by cleavage… Click to show full abstract
The reaction of 2-unsubstituted imidazole N-oxides with ethyl cyanoacetate and aromatic aldehydes leads to the formation of ethyl 2-cyano-2-(1,3-dihydro-2H-imidazole-2-ylidene)acetates. The reaction proceeds through an initial [3+2] cycloaddition, followed by cleavage of the cycloadduct and regeneration of the aldehyde, which essentially plays a catalytic role.
Keywords:
ethyl cyanoacetate;
aldehyde catalyzed;
unexpected aldehyde;
imidazole oxides;
reaction;
oxides ethyl
Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!