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A metal-free oxidative dearomatization of indoles with aromatic ketones mediated by TEMPO oxoammonium salt is described. The dearomatization proceeds smoothly and displays a broad substrate scope with respect to both… Click to show full abstract
A metal-free oxidative dearomatization of indoles with aromatic ketones mediated by TEMPO oxoammonium salt is described. The dearomatization proceeds smoothly and displays a broad substrate scope with respect to both indoles and aromatic ketones in the presence of H2SO4, affording the corresponding 2,2-disubstituted indolin-3-ones in good yields.
Keywords:
aromatic ketones;
oxidative dearomatization;
disubstituted indolin;
indoles aromatic;
dearomatization indoles
Journal Title: Synthesis
Year Published: 2019
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!