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An oxidative desymmetrization of isoindolines was realized by TBN initiated radical sp3 C–H activation relay (CHAR), providing a series of ω-hydroxylactams in high yields. This reaction exhibits broad substrate scope… Click to show full abstract
An oxidative desymmetrization of isoindolines was realized by TBN initiated radical sp3 C–H activation relay (CHAR), providing a series of ω-hydroxylactams in high yields. This reaction exhibits broad substrate scope and functional group tolerance, and even N-alkyl isoindolines can be well tolerated. The mechanistic study shows that the C–H bond oxidation, dioxygen trapping and intramolecular 1,5-H shift might be the key steps to achieve the oxidative desymmetrization.
Keywords:
initiated radical;
desymmetrization isoindolines;
oxidative desymmetrization;
desymmetrization;
isoindolines realized;
tbn initiated
Journal Title: Synthesis
Year Published: 2021
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Journal Title: Synthesis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!