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A synthesis of benzothiazole derivatives through the reaction of 2-halo-N-allylanilines with K2S in DMF is developed. The trisulfur radical anion S3·–, which is generated in situ from K2S in DMF,… Click to show full abstract
A synthesis of benzothiazole derivatives through the reaction of 2-halo-N-allylanilines with K2S in DMF is developed. The trisulfur radical anion S3·–, which is generated in situ from K2S in DMF, initiates the reaction without transition-metal catalysis or other additives. In addition, two C–S bonds are formed and heteroaromatization of benzothiazole is triggered by radical cyclization and H-shift.
Keywords:
benzothiazole;
synthesis benzothiazole;
reaction halo;
benzothiazole derivatives;
halo allylanilines;
synthesis
Journal Title: Synthesis
Year Published: 2020
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2020
Link to full text (if available)
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recommendations!