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We describe the first total synthesis of the recently discovered pyrano[3,2-a]carbazole alkaloid clausenalansine A. The synthetic strategy for the construction of this formylpyrano[3,2-a]carbazole is based on a sequence of Buchwald–Hartwig… Click to show full abstract
We describe the first total synthesis of the recently discovered pyrano[3,2-a]carbazole alkaloid clausenalansine A. The synthetic strategy for the construction of this formylpyrano[3,2-a]carbazole is based on a sequence of Buchwald–Hartwig coupling, palladium(II)-catalyzed oxidative cyclization, Lewis acid promoted annulation of the pyran ring, and chemoselective oxidation of a methyl to a formyl group.
Keywords:
carbazole alkaloid;
first total;
total synthesis;
pyrano carbazole;
alkaloid clausenalansine
Journal Title: Synthesis
Year Published: 2020
Link to full text (if available)
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Journal Title: Synthesis
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!