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We report a reductive allylic defluorinative reaction of α-trifluoromethyl alkenes with terminal epoxides, which consists of an iodide-mediated regioselective ring opening and a nickel-catalyzed radical-type cross-coupling, providing diverse tertiary gem-difluorobishomoallylic… Click to show full abstract
We report a reductive allylic defluorinative reaction of α-trifluoromethyl alkenes with terminal epoxides, which consists of an iodide-mediated regioselective ring opening and a nickel-catalyzed radical-type cross-coupling, providing diverse tertiary gem-difluorobishomoallylic alcohols in moderate to high yields. Notably, this reaction is conducted under mild conditions and requires no external ligand or proton donor.
Keywords:
trifluoromethyl alkenes;
allylic defluorinative;
reductive allylic;
nickel catalyzed;
cross coupling
Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
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Journal Title: Synlett
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!