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An asymmetric formal synthesis of trichodermamides B and C was achieved in 15 steps based on a tyrosine ester chiral-pool approach. Key features of this synthesis include stereoselective construction of… Click to show full abstract
An asymmetric formal synthesis of trichodermamides B and C was achieved in 15 steps based on a tyrosine ester chiral-pool approach. Key features of this synthesis include stereoselective construction of a cis-1,2-oxazadecaline core by an acid-mediated tandem deprotection–intramolecular oxy-Michael reaction, oxime ether formation via an N-bromination–elimination sequence, and diene construction by a palladium-catalyzed demonomethylcarbonation.
Keywords:
asymmetric formal;
synthesis trichodermamides;
formal synthesis
Journal Title: Synlett
Year Published: 2021
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Journal Title: Synlett
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!