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Idiopathic Hypoparathyroidism Presenting As New Onset Refractory Status Epilepticus

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A 23-year-old male, presented with a flurry of new onset generalized tonic clonic seizures and impaired sensorium. Hewas intubated andmanaged as a case of status epilepticus with intravenous lorazepam followed… Click to show full abstract

A 23-year-old male, presented with a flurry of new onset generalized tonic clonic seizures and impaired sensorium. Hewas intubated andmanaged as a case of status epilepticus with intravenous lorazepam followed by multiple anti seizure medications (ASM) and midazolam infusion. His initial laboratory reports revealed hypocalcemia (4.8mg/dL) (ref range: 8–11mg/dL) with normal sodium, potassium, magnesium, and phosphorus levels. His blood sugar, renal, and liver function tests were also within normal limits. Further evaluation showed low intact parathyroid hormone <3 pg/mL (ref range: 15–68.3 pg/mL) and Vitamin D3 (22 ng/mL) (ref range 30–100 ng/mL) levels. Computed tomography (CT) of brain showed calcifications in bilateral caudate, lentiform nucleus, and cerebellar hemispheres (►Fig. 1A, B). Ultrasound abdomen and CT scan of neck were normal. With the diagnosis of idiopathic hypoparathyroidism, he was treated with parenteral and oral calcium preparations, along with Vitamin D3 under cardiac monitoring. With correction of hypocalcemia his seizures got controlled; he was extubated and ASM were tapered. He

Keywords: status epilepticus; idiopathic hypoparathyroidism; new onset; ref range

Journal Title: Journal of Neurosciences in Rural Practice
Year Published: 2021

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