LAUSR

Soft tissue fi llers are common aesthetic procedures for facial rejuvenation. 1 Among the fi llers in the market, hyaluronic acid fi ller has been the most popular because it is degraded by hyaluronidase. The most serious complications of fi ller injections are vascular complications, such as skin necrosis and ocular sequelae. Various treatment mo-dalities, including hyaluronidase injection, have been pro-posed. Hyaluronidase, which normally exists in human tissues, dissolves hyaluronic acid. It degrades the β 1,4 chain of the disaccharide hyaluronic acid. The hyaluronic acid fi ller can be degraded by hyaluronidase when vascular complications develop. However, multiple factors must be considered before injecting hyaluronidase. This report pro-posed fi ve important considerations for hyaluronidase injection.