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Synthesis and Optical Resolution of Inherently Chiral Fluorescent Calix[4]arenes and Their Application in Chiral Recognition

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Inherently chiral calix[4]arenes were separated by condensation with chiral auxiliary (S)- and (R)-1-phenylethylamine using column chromatography on silica gel; subsequent derivatization with click chemistry furnished compounds with fluorescent properties that… Click to show full abstract

Inherently chiral calix[4]arenes were separated by condensation with chiral auxiliary (S)- and (R)-1-phenylethylamine using column chromatography on silica gel; subsequent derivatization with click chemistry furnished compounds with fluorescent properties that can be used for chiral recognition.

Keywords: chiral recognition; calix arenes; synthesis; inherently chiral

Journal Title: Synthesis
Year Published: 2023

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