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We thank Ludwig et al. for their interest in our work (1) and for bringing a revealing aspect of cerebrospinal fluid (CSF) dynamics to our attention (2). The flow reversal… Click to show full abstract
We thank Ludwig et al. for their interest in our work (1) and for bringing a revealing aspect of cerebrospinal fluid (CSF) dynamics to our attention (2). The flow reversal of the internal CSF circulation during forced breathing maneuvers in interrelation with cranial and thoracic venous vasculature responses demonstrated by their research group may in fact be part of a general mechanism that we aim to confirm to be at the core of our findings and other cranial changes observed during and after long-duration spaceflight (3⇓–5). This presumed mechanism is a profound reduction of the bulk flow from CSF space into the dural veins in … [↵][1]1To whom correspondence may be addressed. Email: Peter.zu.Eulenburg{at}med.uni-muenchen.de. [1]: #xref-corresp-1-1
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2019
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